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Figure 1 A metabolite set enrichment analysis made from the 31 metabolites significantly modulated by MTX confirmed the major impact of the drug on glycine and serine metabolism, the urea cycle, alanine metabolism, and arginine and proline metabolism ( Figure 1B )
Their comparison illustrates the two dominant strategies in modern obesity pharmacotherapy: combination therapy with proven agents versus novel single-molecule multi-agonism
Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: a randomized controlled trial
Cell viability Resazurin reduction assay Resazurin (Sigma) was added to the cell culture medium (5 g/ml) for a period of at least 30 min
Kratzer I, Liddelow SA, Saunders NR, Dziegielewska KM, Strazielle N, Ghersi-Egea JF
10.1186/s40893-016-0012-0 88
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