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Melatonin has the potential to be used as a combination therapy option in pancreatic ductal adenocarcinoma (PDAC) because, in addition to modulating the Kirsten rat sarcoma viral oncogene homolog ( KRAS ), it upregulates the tumor suppressor genes p21 , p27 , and p57 in combination with cisplatin and cetuximab [76]
Nausea, constipation, diarrhea, bloating, and reduced appetite are reported with both
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