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JAMA 282 , 15681575 (1999)

Future work should focus on 3D cultures and in vivo animal models that more accurately mimic a natural cellular environment, allowing a true evaluation of the peptides effectiveness as an anti-aging compound

SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells

Both compounds were on the FDA's 503A Category 2 list substances raising significant safety concerns and effectively blocked from compounding pharmacies until April 22, 2026