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Epithalon has been shown in multiple studies to reduce markers of oxidative stress, including lipid peroxidation byproducts and 8-hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage

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A 2025 systematic review published in the International Journal of Dermatology reviewed the clinical evidence for glutathione as a skin-lightening agent

Unfortunately, studies on this topic have mainly focused on normalising serum B12 concentrations with oral supplementation and should be interpreted with caution since the specific goal of treatment in symptomatic B12 deficiency is alleviating symptoms, and NOT to normalize B12 concentrations in the blood