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Metabolism of ethinylestradiol and levonorgestrel occurs mainly in the liver but also in the gastrointestinal tract [24] via CYP enzymes, particularly by CYP3A4, which is expressed in the liver and intestine [25]

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Nevertheless, our findings also suggest an increased efficacy of GLP-1RAs in a post-bariatric population, compared with people with obesity with no history of bariatric interventions

doi: 10.1210/jc.2012-3855 62 SukumaranV.TsuchimochiH.SonobeT.ShiraiM.PearsonJ

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