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Who Should Start GLP-1 Treatment and How Genetics May Inform Provider Conversations GLP-1 medications are appropriate for adults with a BMI 30 or 27 with weight-related comorbidities (hypertension, type 2 diabetes, cardiovascular disease), provided no contraindications exist
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Ethics statement The studies involving humans were approved by the University of Helsinki, Faculty of Medicine
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Oxidized semaglutide may have reduced receptor binding affinity, meaning it is less effective at activating the GLP-1 receptor
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