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The glucose-dependence that makes them safe, the central action that drives weight loss, the cardiovascular and renal benefits, and the gastrointestinal side effects all trace back to where the receptor sits and how it signals

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Hormone replacement therapy works by replacing the sex hormones that decline at menopause, which is a different mechanism entirely

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The menopause transition only added to the challenge, as both Rock and Reed-Smith had to untangle the overlapping effects of hormones, aging and medication on their libido

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