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Combination with metformin or metformin with sulfonylurea In a 30-week, open-label trial (NCT02128932), 1089 patients with type 2 diabetes mellitus were randomized to OZEMPIC 0.5 mg once weekly, OZEMPIC 1 mg once weekly, or insulin glargine once daily on a background of metformin (48%) or metformin and sulfonylurea (51%)
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People taking the contraceptive pill are advised to use a back-up contraceptive for this reason if they vomit or have diarrhoea to avoid unintended pregnancy
Considering a 20% dropout rate, the sample size will be inflated to 250 (approximately 63 per group) is required
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![Chemical structure of L-Carnitine [4]](https://www.researchgate.net/publication/373158466/figure/fig1/AS:11431281181839341@1692197801770/Chemical-structure-of-L-Carnitine-4.png)
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