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Researchers have administered doses hundreds of times higher than typical human protocols without observing toxic effects

In addition, in contrast to other cellular mediators, miRNAs can be easily manipulated and therapies based on antimiRs or miRNA mimics are now being developed to repress pathological miRNAs (Small and Olson, 2011) or to overexpress protective miRNAs (Small and Olson, 2011), respectively

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