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In addition, 2-oxoglutarate may also serve as a transcriptional modulator via activation of 2-oxoglutarate oxygenase, which has several biological roles, including demethylation of histones and nucleic acids, and destabilization of transcriptional factor HIF-1 42

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Cheng X, Golemovic M, Giles F, Arlinghaus R, M-Z G, Freireich EJ, Andreeff M , Kantarjian HM, Verstovsek S

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