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Glia 22:1118 Kussmaul L, Hamprecht B, Dringen R (1999) The detoxification of cumene hydroperoxide by the glutathione system of cultured astroglial cells hinges on hexose availability for the regeneration of NADPH

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Metformin functions by activating AMPK, which inhibits hepatic lipid synthesis, enhances hepatic fatty acid oxidation, facilitates the phosphorylation of target substrates, and supports mitochondrial function and adipose tissue integrity