Canagliflozin significantly inhibits inflammatory factor expression, including cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase, exerting cardioprotective effects by regulating inflammation and ferroptosis through the AMP-activated protein kinase (AMPK) pathway (83)
Microglia are involved in various aspects of DCI, including neuro-inflammation, vasospasm, microthrombosis, and cortical spreading depolarizations ( Microglia contribute to sustained neuro-inflammation and vasospasm through the release of proinflammatory cytokines like TNF, which promotes vasoconstriction (89)
Iron and Calcium Supplements Risk: poor absorption and potential GI side effects Choose well-absorbed forms and avoid taking with antacids or thyroid meds
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Along with vitamin C, vitamin B12 might interact with other substances