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Release of basal GnRH was found to be increased during the proestrous and diestrous I in hypothalamic slices of ALC-treated rats, which could mean that ALC stimulates the secretory activity of GnRH-producing hypothalamic neurons
According to one study, this resulted in the drugs improved efficacy, compared with semaglutide, as glucagon receptor agonism in the liver and adipose tissue resulted in increased energy expenditure
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Impaired incretin effect and fasting hyperglucagonaemia characterizing type 2 diabetic subjects are early signs of dysmetabolism in obesity
Annexes 2024 Annual Report of the European Medicines Agency
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