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Phase 3 results reported through May 2026 show retatrutide produced mean weight loss of up to 28.3% at 80 weeks and 30.3% at 104 weeks in non-diabetic populations, with gastrointestinal adverse events the most common reported safety signal

Read the CJC-1295 trial

doi: 10.1111/j.1471-4159.2010.07132.x 81 WeigelKJLynchSGLevineSM

I work towards building therapeutic trust in order to work towards processing and building coping skills to manage life's everyday stressors

Common gastrointestinal side effects include: Nausea the most frequently reported side effect, particularly during dose escalation Vomiting often linked to nausea and typically dose-dependent Diarrhoea and constipation both have been reported, reflecting altered gut motility Decreased appetite a desired therapeutic effect, but one that requires monitoring to ensure adequate nutrition Severe or prolonged vomiting and diarrhoea can lead to dehydration and, in some cases, acute kidney injury (AKI)