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In summary, GLP-1RAs provide substantial weight loss and cardiometabolic benefits but may compromise skeletal muscle integrity, whereas exercise supports muscle maintenance and functional health, though its effect on weight reduction is typically modest compared with pharmacotherapy

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With a data-informed approach, we can identify and prioritize those in greatest need and match individuals to treatments from across the full care spectrum, including intensive behavioral therapy, non-GLP medications, GLPs, and bariatric surgery

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Although more research is needed to determine whether these savings can offset the upfront cost of these drugs, the trend lines appear positive, said Zvenyach