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Addressing only one bottleneck leaves others unaffected
However, during the ice age, animals exhibited unique amino acid substitutions at some conserved sites
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Compared with normal skin fibroblasts, a greater number of keloid fibroblasts displayed a senescent phenotype and were arrested at the G0/G1 phase using a serum-limited culture approach, indicating the senescent tendency of keloid fibroblasts under simulated ischemic stress
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