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However, the risk for thyroid cancer was significantly higher within the first year after GLP-1RA initiation and was amplified in the overall as-treated analysis that censored patients when therapy was discontinued or another medication was added. The research team indicates this could be a sign that GLP-1 users are being screened for thyroid cancer at a higher rate than other diabetes drugs, resulting in a spike in diagnoses in the first year of taking the drug

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If these develop, ultrasound evaluation is necessary

The approved Wegovy schedule starts at 0.25 mg/week for 4 weeks, escalates through 0.5 mg, 1.0 mg, and 1.7 mg, reaching the maintenance dose of 2.4 mg/week at week 17 [3]