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In prospective clinical trials (study number DRKS00000365 and UKF001822), by analyzing the growth factor content in the synovial fluid of patients with OA, they found the IGF-1 concentration in the joints with cartilage lesions was significantly increased compared to healthy samples [54]

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Statistics by two-sided unpaired t-tests compared to sgControl cells (d-f, j-l)

& Lemaire, S