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Individuals with a personal or family history of medullary thyroid carcinoma or MEN2 are typically excluded from trials due to precautionary class-effect concerns

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for type 2 diabetes mellitus (T2DM) and weight management, have emerged as a promising treatment due to their anti-inflammatory and immunomodulatory properties

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