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Besides metabolite detoxification, GST also exhibits ligand-binding properties that initiate cellular apoptosis when triggered by cellular stress

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To our knowledge, this has been documented to date in only one report showing that patients with NAFLD had increased hepatic protein glutathionylation, which was correlated with steatohepatitis and liver fibrosis 40

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These are typically temporary and often dose-dependent, meaning they can improve over time or with a dosage adjustment