Notably, Trulicity carries a higher risk of low blood sugar (hypoglycemia) when used with insulin or sulfonylureas (up to 20%), while Zepbound shows lower hypoglycemia rates (~5%)
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews
You talked about theres a million diets out there and theres a million different people out there
(PubMed) Zhang M, Robitaille L, Eintracht S, Hoffer LJ
The honest answer is probably yes, with the right oversight, the right titration, and a plan that doesn't assume the drug does all the work
The goal is to isolate the peptide effect from background variability