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Plateaus are common and manageable

It lists age, sex, baseline weight, and previous medication exposure among the factors shaping how quickly results appear, and specifically says older adults or those with prior GLP-1 exposure can require a longer adaptation period

The goal is to avoid the regain-restart cycle by continuing maintenance therapy from the start

Rotating injection sites helps reduce this

Semaglutide does not affect menstrual bleeding, cycle length, or estrogen and progesterone production

Additionally, GLP-1 medications can cause nausea, vomiting, and diarrhea, particularly during dose escalation phases