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Contraindications and Use Restrictions GLP-1 medications should not be used by individuals with a personal or family history of medullary thyroid carcinoma, Multiple Endocrine Neoplasia syndrome type 2, known hypersensitivity to semaglutide, or during pregnancy or breastfeeding

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Cumene hydroperoxide concentration is also increased from 12 mM up to 60 mM so that lipid peroxidation is increased and GP activity therefore is limited only by GP levels in RBC membrane preparations