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Phase 1 trial data included groups that started directly at higher doses, and while efficacy was not compromised, GI side effect rates nearly doubled compared to the gradual approach

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The active factor turned out to be a small tripeptide that tightly bound copper

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Branched-chain amino acids, known as BCAAs, are a group of amino acids and they account for over one third of the protein in the body's muscles

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A detailed comparison of many studies of passive immunization with nAbs against SHIV challenge in macaques, showing that relatively high serum titres are generally required for protection consistent with the AMP trials

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the WHO 2021 no-safe-level guideline

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10.1016/j.cmet.2012.08.012 184

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