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Rebound on discontinuation: Most patients regain a substantial portion of lost weight within 12 months of stopping treatment, because the underlying metabolic drivers were not addressed

Many patients find this dose sufficient

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This escalation pattern is consistent with other GLP-1 receptor agonists and should be considered when designing preclinical study protocols that aim to replicate clinical pharmacokinetics

Research suggests BPC-157 may downregulate VEGF expression in tumor contexts while upregulating it during normal healing