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This study found both drugs to be similar in terms of major adverse cardiac events (known as MACE, and include heart attack, stroke, and death due to heart-related causes) as well as heart failure hospitalization and death by any cause

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However, further dose-response analysis and adjustment for intake of other vitamin and mineral supplements indicated that all-cause mortality risk was significantly increased by 7% only at a dose of 2,000 IU/day, which is notably higher than the UL for adults (1,100 IU/day of synthetic tocopherol or 1,500 IU/day of natural tocopherol)

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Certain genetic variations in MTHFR and PEMT, enzymes involved in methylation and choline synthesis, respectively, have been linked to increased dietary choline requirements

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