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This improvement is attributed to increased GLP-1 activity and direct inhibition of DPP-4 expressed in the liver [119]
There is a mild positive fat-mobilization effect and appetite suppressor effect as well
Our bodies can only handle so much glucose and fructose
Further research is needed to identify effective and practical oral therapies that provide sustained weight reduction with acceptable safety profiles
The results in our study that were most analogous to RCT results were among the top 10% of treated respondents for weight loss (i.e., average reduction of 15% at 12 months) and HbA1c (i.e., average reduction of 3% at 12 months), while the bottom 10% of treated respondents saw no change or slightly worsening outcomes over time
What hasn't kept pace with that ubiquity is a clear picture of how they actually work and how they're best used
