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Importantly, curcumin demonstrates a multifaceted epigenetic influence that encompasses the inhibition of DNA methyltransferases leading to DNA demethylation and reactivation of silenced tumor-suppressor genes, modulation of histone acetylation and methylation balance to restore normal chromatin accessibility, regulation of non-coding RNAs such as microRNAs, lncRNAs, and circRNAs that control gene expression, and alteration of RNA methylation (m 6 A modification) through modulation of METTL3, FTO, and YTHDF proteins, which influence mRNA stability and translation efficiency

Demonstrating some passage in an animal model does not establish predictable human brain exposure from a commercial formulation