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In 2025, a landmark study revealed that patients with severe obesity lost an average of 11.9% of their body weight after a year of consistent injectable therapies like semaglutide
Crain TL, Hammer LB, Bodner T, Olson R, Kossek EE, Moen P, Buxton OM
This coincided with in vitro inhibition of RBL-2H3 mast cell degranulation upon formononetin treatment (10, 20, 40 M) with suppression of morphological changes and cytoskeletal decomposition, mediated by NF-B signaling
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This process is regulated both transcriptionally and through posttranslational modifications driven by nutrient and redox status 16
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