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Measure against baseline weekly

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With respect to dosage, the average reductions were: 2000 mcg: 71.5% (single data point) 1,000 mcg: 31.8% Although limited data are available for higher dosages, the findings support the efficacy of both oral and non-oral B12 formulations in modulating homocysteine levels

It was not drug approval, and the FDA has not made a final decision

Individuals with known B12 deficiencies, or those prone to a potential deficiency due to their lifestyle, must supplement vitamin B12