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Data are mean SEM, n = 8/group

doi: 10.3389/fcdhc.2025.1718498 7 WangJPiHSunQ

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The combination therapy of metformin and CDDP weakens ERK-mediated phosphorylation of NRF2, enhances its polyubiquitination, and promotes its proteasomal degradation, thereby significantly reducing the levels of NRF2 in A549/DDP and H838 NSCLC cells, promoting ROS-mediated apoptosis

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