Holz GGT, Leech CA, Habener JF
In epidemiology, effects of this magnitudeespecially when observed repeatedly across large populationsare considered clinically meaningful rather than trivial statistical artifacts
10.1016/j.bbrc.2017.06.075 181 ZajdelP.MarciniecK.SataaG.CanaleV.KosT.PartykaA.et al (2016)
More profound benefitsincluding histological improvement in non-alcoholic steatohepatitis (NASH)are observed with weight loss exceeding 7% [123, 124]
Oral GLP-1 therapies are frequently associated with gastrointestinal side effects, including nausea, diarrhea, constipation, and vomiting
In the few that did develop tumors, the tumors were small compared to those of wild-type mice