What exactly are GLP-1 medications like Semaglutide and Tirzepatide
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr., Sperling L, Virani SS, Yeboah J
Although limited, the evidence suggests that combined therapy has an enhanced effect in reducing cardiovascular events in selected populations and positively impacting important surrogate kidney disease markers
However, Xu 2024 offers something Pei did not: detailed subgroup analyses by needle depth and treatment duration
Consistently, deletion of miR-148a or miR-152 binding regions in 3UTR of IRS-1 did not exert the effect of miR-148a or miR-152 overexpression on inhibition of cell proliferation, indicating that these miRNAs affect cancer cell proliferation via IRS-1 suppression
It may protect brain cells from oxidative stress, potentially slowing neurodegenerative diseases like Alzheimers and Parkinsons