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"Way back, when there really weren't too many other agents for obesity treatment," she'd prescribe more of it, she told Insider, but that was largely because "there wasn't anything else." But metformin's effects on weight loss are "kind of mild," compared to newer drugs like semaglutide, Apovian said, and persistent side effects like stomach cramps and diarrhea are a common concern among patients taking metformin

However, the FDA has issued a black box warning for thyroid C-cell tumors

GLP-1 patches are designed to deliver medication continuously through the skin, maintaining steady drug levels, whereas injections create peak-and-trough concentration patterns

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Greater number of capillary endothelial cell mitochondria in brain than in muscle

doi: 10.1371/journal.ppat.1007390 209 OnofrioL.CaragliaM.FacchiniG.MargheritaV.De PlacidoS.BuonerbaC