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Retatrutide: The Triple Receptor Compound The compound at the center of this shift, retatrutide, hits three receptors at once: GLP-1, GIP, and glucagon
Slow titration if rapid weight loss threatens lean mass or nutrition
JACC 82(9):833955 Rangaswami J, Bhalla V, de Boer IH, Staruschenko A, Sharp JA, Singh RR et al (2020) Cardiorenal protection with the newer antidiabetic agents in patients with diabetes and chronic kidney disease: a scientific statement from the American Heart Association
Nadler adds
Its metabolic regression that makes long-term maintenance harder
Treatment plans are individualized, and dosing is gradually adjusted under medical supervision to support tolerability and safety
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