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Ozdemir Kutbay et al., 2020) in several TC models ( These in vitro studies make metformin desirable for potential repositioning as anti-cancer compounds in the treatment of TC, thus several studies are still ongoing to deeply characterize its effect

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No major toxicological red flags have been identified in preclinical studies

Sanyal Arun J, Pierre B, Mandy F, Neff Guy W, Eric L, Elisabetta B et al

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But those options are still in trials