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The mechanism behind oral efficacy is attributed to systemic absorption and downstream peptide signaling rather than localized delivery, though the exact bioavailability percentage in humans remains unquantified

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This is thought to occur through modulation of key signaling pathways like NF-B

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Molecular dynamics simulations Molecular dynamics simulations have been performed using the AMBER ff19SB force field 57 and the solvent molecules were represented as OPC water molecules 58