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This mechanism distinguishes it from semaglutide, which primarily targets GLP-1, and tirzepatide, which targets GLP-1 and GIP
AhrnBSimonssonELarssonHLandin-OlssonMTorgeirssonHJanssonPAet al
in vivo and in vitro studies
Strange RC, Davis BA, Faulder CG, Cotton W, Bain AD, Hopkinson DA et al
This can lead to dysregulation of the reninangiotensinaldosterone system resulting in poor health outcomes and, in many cases, death 11
Meta-analyses and head-to-head clinical trials consistently show that GLP-1 receptor agonists outperform other diabetes treatments in reducing HbA1c and body weight
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