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Additionally, metformin has demonstrated anti-inflammatory effects through the inhibition of IL-18 expression, which is linked to alterations in the intestinal microbiome (Lee et al., 2019)
This reduces variance between research runs
Whole grains instead of refined grains
Some patients on Contrave do report mild energy shifts from the bupropion component, since bupropion has a slight stimulant-like effect on some people
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