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A large number of studies have demonstrated the neuroprotective ability of GLP-1 RA, resulting in the improvement of cognitive and non-cognitive dysfunction of the central nervous system (CNS)
Blood pressure lowering in type 2 diabetes
For hypothyroid patients, this combination can be transformative
Activation and inhibition of sodium-hydrogen exchanger is a mechanism that links the pathophysiology and treatment of diabetes mellitus with that of heart failure
Exendin-4 increases mRNA expression of Il1b, Il6, Il22, Il12b, Tnfa, Ccl2, Cxcl1 , and Cxcl2 (innate immunity), regenerating islet-derived protein 2, RegIIIy and RegIIIB (anti-microbial proteins), as well as Il-5, Il-13 (pathogen clearance) within 4 h of administration, returning to baseline expression by 24 h (Yusta et al., 2015), suggesting that GLP-1R activation engages a cytoprotective response
Obesity alone is a major contributor to heart disease, stroke, cancer, diabetes, and arthritis key causes of death and disability
