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In a Phase II trial, retatrutide demonstrated a mean weight reduction of over 17.5% in adults without diabetes but with obesity or pre-obesity, marking a significant advancement in weight management therapies
Managing your weight and understanding your caloric needs can be challenging, especially when youre taking GLP-1 medications such as Ozempic, Wegovy, Semaglutide, Mounjaro, Zepbound, Tirzepatide, Liraglutide, Saxenda, Trulicity, and Victoza
If something isnt working, we adjust your protocol
A large meta-analysis of 45 RCTs recently found that compared with placebo or other interventions, GLP-1RAs did not increase the risk of thyroid cancer, hyperthyroidism, hypothyroidism, thyroiditis, thyroid mass, and goiter [69]
Acta MedicaMediterranea 32:16431649 Bush AI, Tanzi RE (2008) Therapeutics for Alzheimer's disease based on the metal hypothesis
Given the above and current knowledge, a clinically significant DDI between GLP1RAs and COCs is probably not expected, and there is no recommendation in any GLP1RA prescription sheet for dose adjustment of COCs in this context
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