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Serious risks reported with GLP-1 therapy include pancreatitis, gallbladder problems, low blood sugar (particularly alongside other diabetes medicines), kidney issues from dehydration, and allergic reactions

one had papillitis, which is inflammation of the optic nerve head

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As researchers discover more, they may determine which populations benefit most or who should steer clear because of side effects

Some studies suggest the quinolinium structure is sufficiently NNMT-selective that it should not broadly deplete SAM, but the wider metabolic picture remains an active research consideration