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The pathophysiology of ischaemic stroke is defined by the limitation of oxygen supply (hypoxia or anoxia), and restricted supply of metabolic substrates
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R Methylation: SAM-dependent methyltransferases catalyze the SN2 transfer of the methyl group from the sulfonium center of SAM-e to an electron-rich acceptor atom (O, N, or S) on the substrate, producing the methylated product and SAH
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