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In a normal heart, electrical signals coordinate the hearts contractions, ensuring that it beats in a regular rhythm

Michaels Hospital, University of Toronto) at the American Diabetes Associations 2024 Scientific Sessions and published in the Journal of the American College of Cardiology

Conversely, poor sleep creates a negative cycle: insulin resistance worsens, hunger hormones increase, energy drops, activity decreases, and sleep quality further declines

Similar microglial changes were seen in the ALS mouse model, with CD68 increasing first, followed by L-ferritin, after TDP-43 inclusions appeared (Swanson et al., 2023)

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Those factors could help explain the benefits seen in heart failure patients, cardiologist Barry Borlaug reported at the meeting and in Nature Medicine