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We critically evaluate how key host factors, such as gut microbiota composition and glutathione S-transferase (GST) polymorphisms, dictate SFN bioavailability and efficacy, thereby framing a precision nutrition paradigm for its application

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American J Gastroenterology 117(9):13871389

While the molecular alterations identified were robust and internally consistent, validation in larger, independent cohorts will be important to confirm our findings and assess inter-individual variability

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[ref] Related article: GST Enzymes and Glutathione for Environmental Toxins UGT1A family and estrogenic mycotoxins (zearalenone, ochratoxin A): UGT1A1, UGT1A3, and UGT1A8 enzymes glucuronidate zearalenone, reducing its estrogenic activity and promoting excretion from the body