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As with other GLP-1-based therapies, the most commonly reported side effects of retatrutide in clinical trials are gastrointestinal in nature

Reduced milk volume

95 Additionally, in the pancreas and adipose tissue, GLP-1, a substrate of DPP4, has demonstrated anti-inflammatory properties by reducing the production of inflammatory cytokines and immune cell infiltration

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Its important to understand that most side effects are usually mild to moderate

Your cells become "deaf" to insulin's signals, so your body pumps out more and more insulin to compensate