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doi: 10.12890/2021_002807 65 BostanHUcanBKizilgulMCalapkuluMHepsenSGulUet al
What Clinical Trials Show at Studied Doses Microdosing discussions often reference full-dose research because those trials are the only rigorous data available for understanding how these medications behave
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The studies demonstrated the importance of not only the amino acid residue isoleucine 253 (I253) in the IgG Fc, but also of histidines (including H310 and H435), the pKa of which results in protonation/deprotonation in the endosomal pH range
