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The clinical evidence does not support biweekly dosing as a substitute for weekly administration
Ultimately the goal of treatment is to improve health, not what people see in the mirror. Although NICE says that semaglutide can be offered for only two years, Prof le Roux expects this to change
It enrolled 751 adults and ran for 72 weeks at the maximum tolerated dose of each drug
Tirzepatide is the active ingredient of Mounjaro, which is classified as a brand-name dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist
Supplementary Information Additional file 1 (download DOCX : Title of data: GRIPP2 table of patient and public involvement*
[1] NICE guidance (NG28) recommends GLP-1 receptor agonists like semaglutide for adults with type 2 diabetes when: Triple therapy with metformin and two other oral drugs is ineffective, not tolerated, or contraindicated The person has a BMI of 35 kg/m or higher (adjusted for ethnicity) and specific psychological or medical problems associated with obesity BMI is lower than 35 kg/m but insulin therapy would have significant occupational implications or weight loss would benefit other obesity-related comorbidities Ozempic is available in pre-filled, multi-dose pens delivering 0.25 mg, 0.5 mg, 1 mg, or 2 mg doses
