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8.4.4 Translation of preclinical evidence to clinical practice: critical methodological gaps A systematic evaluation of the evidence base presented in this review reveals significant translational barriers between preclinical mechanistic studies and clinical efficacy validation
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Furthermore, IFN-induced arginine depletion, subsequent GCN2 expression, and autophagy contribute to the transformation of bovine epithelial mammary cells and tumorigenesis [94]
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