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The SURPASS-1 trial investigated the efficacy and safety of the three doses of 5, 10, or 15 mg tirzepatide in drug-nave patients with T2D who were not sufficiently controlled with a lifestyle intervention with diet and exercise versus placebo (70)

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5.2 Regulation of T cell subtypes CD4/CD8 and Treg cells by GLP-1RA GLP-1R is expressed in various immune cell populations of NOD mice, with a higher proportion of mature CD4 + and CD8 + T cells (approximately 5%-6%)

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